Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar.
Identifieur interne : 003198 ( Main/Exploration ); précédent : 003197; suivant : 003199Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar.
Auteurs : Jun Won Kang [États-Unis] ; Hui-Wen Wilkerson ; Federico M. Farin ; Theo K. Bammler ; Richard P. Beyer ; Stuart E. Strand ; Sharon L. DotySource :
- Functional & integrative genomics [ 1438-7948 ] ; 2010.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Analyse de profil d'expression de gènes (MeSH), Animaux (MeSH), Cytochrome P-450 CYP2E1 (métabolisme), Lapins (MeSH), Populus (effets des médicaments et des substances chimiques), Populus (génétique), RT-PCR (MeSH), Régulation de l'expression des gènes végétaux (effets des médicaments et des substances chimiques), Séquençage par oligonucléotides en batterie (MeSH), Trichloroéthylène (pharmacologie), Végétaux génétiquement modifiés (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Populus, Régulation de l'expression des gènes végétaux.
- génétique : ARN messager, Populus.
- métabolisme : ARN messager, Cytochrome P-450 CYP2E1.
- pharmacologie : Trichloroéthylène.
- Analyse de profil d'expression de gènes, Animaux, Lapins, RT-PCR, Séquençage par oligonucléotides en batterie, Végétaux génétiquement modifiés.
English descriptors
- KwdEn :
- Animals (MeSH), Cytochrome P-450 CYP2E1 (metabolism), Gene Expression Profiling (MeSH), Gene Expression Regulation, Plant (drug effects), Oligonucleotide Array Sequence Analysis (MeSH), Plants, Genetically Modified (MeSH), Populus (drug effects), Populus (genetics), RNA, Messenger (genetics), RNA, Messenger (metabolism), Rabbits (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Trichloroethylene (pharmacology).
- MESH :
- chemical , genetics : RNA, Messenger.
- chemical , metabolism : Cytochrome P-450 CYP2E1, RNA, Messenger.
- drug effects : Gene Expression Regulation, Plant, Populus.
- genetics : Populus.
- chemical , pharmacology : Trichloroethylene.
- Animals, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Plants, Genetically Modified, Rabbits, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Trichloroethylene (TCE) is an important environmental contaminant of soil, groundwater, and air. Studies of the metabolism of TCE by poplar trees suggest that cytochrome P450 enzymes are involved. Using poplar genome microarrays, we report a number of putative genes that are differentially expressed in response to TCE. In a previous study, transgenic hybrid poplar plants expressing mammalian cytochrome P450 2E1 (CYP2E1) had increased metabolism of TCE. In the vector control plants for this construct, 24 h following TCE exposure, 517 genes were upregulated and 650 genes were downregulated over 2-fold when compared with the non-exposed vector control plants. However, in the transgenic CYP2E1 plant, line 78, 1,601 genes were upregulated and 1,705 genes were downregulated over 2-fold when compared with the non-exposed transgenic CYP2E1 plant. It appeared that the CYP2E1 transgenic hybrid poplar plants overexpressing mammalian CYP2E1 showed a larger number of differentially expressed transcripts, suggesting a metabolic pathway for TCE to metabolites had been initiated by activity of CYP2E1 on TCE. These results suggest that either the over-expression of the CYP2E1 gene or the abundance of TCE metabolites from CYP450 2E1 activity triggered a strong genetic response to TCE. Particularly, cytochrome p450s, glutathione S-transferases, glucosyltransferases, and ABC transporters in the CYP2E1 transgenic hybrid poplar plants were highly expressed compared with in vector controls.
DOI: 10.1007/s10142-010-0165-4
PubMed: 20213342
PubMed Central: PMC3050643
Affiliations:
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Farin</name></author><author><name sortKey="Bammler, Theo K" sort="Bammler, Theo K" uniqKey="Bammler T" first="Theo K" last="Bammler">Theo K. Bammler</name></author><author><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P" last="Beyer">Richard P. Beyer</name></author><author><name sortKey="Strand, Stuart E" sort="Strand, Stuart E" uniqKey="Strand S" first="Stuart E" last="Strand">Stuart E. Strand</name></author><author><name sortKey="Doty, Sharon L" sort="Doty, Sharon L" uniqKey="Doty S" first="Sharon L" last="Doty">Sharon L. 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Studies of the metabolism of TCE by poplar trees suggest that cytochrome P450 enzymes are involved. Using poplar genome microarrays, we report a number of putative genes that are differentially expressed in response to TCE. In a previous study, transgenic hybrid poplar plants expressing mammalian cytochrome P450 2E1 (CYP2E1) had increased metabolism of TCE. In the vector control plants for this construct, 24 h following TCE exposure, 517 genes were upregulated and 650 genes were downregulated over 2-fold when compared with the non-exposed vector control plants. However, in the transgenic CYP2E1 plant, line 78, 1,601 genes were upregulated and 1,705 genes were downregulated over 2-fold when compared with the non-exposed transgenic CYP2E1 plant. It appeared that the CYP2E1 transgenic hybrid poplar plants overexpressing mammalian CYP2E1 showed a larger number of differentially expressed transcripts, suggesting a metabolic pathway for TCE to metabolites had been initiated by activity of CYP2E1 on TCE. These results suggest that either the over-expression of the CYP2E1 gene or the abundance of TCE metabolites from CYP450 2E1 activity triggered a strong genetic response to TCE. Particularly, cytochrome p450s, glutathione S-transferases, glucosyltransferases, and ABC transporters in the CYP2E1 transgenic hybrid poplar plants were highly expressed compared with in vector controls.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20213342</PMID><DateCompleted><Year>2010</Year><Month>11</Month><Day>22</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1438-7948</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>3</Issue><PubDate><Year>2010</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Functional & integrative genomics</Title><ISOAbbreviation>Funct Integr Genomics</ISOAbbreviation></Journal><ArticleTitle>Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar.</ArticleTitle><Pagination><MedlinePgn>417-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10142-010-0165-4</ELocationID><Abstract><AbstractText>Trichloroethylene (TCE) is an important environmental contaminant of soil, groundwater, and air. Studies of the metabolism of TCE by poplar trees suggest that cytochrome P450 enzymes are involved. Using poplar genome microarrays, we report a number of putative genes that are differentially expressed in response to TCE. In a previous study, transgenic hybrid poplar plants expressing mammalian cytochrome P450 2E1 (CYP2E1) had increased metabolism of TCE. In the vector control plants for this construct, 24 h following TCE exposure, 517 genes were upregulated and 650 genes were downregulated over 2-fold when compared with the non-exposed vector control plants. However, in the transgenic CYP2E1 plant, line 78, 1,601 genes were upregulated and 1,705 genes were downregulated over 2-fold when compared with the non-exposed transgenic CYP2E1 plant. It appeared that the CYP2E1 transgenic hybrid poplar plants overexpressing mammalian CYP2E1 showed a larger number of differentially expressed transcripts, suggesting a metabolic pathway for TCE to metabolites had been initiated by activity of CYP2E1 on TCE. These results suggest that either the over-expression of the CYP2E1 gene or the abundance of TCE metabolites from CYP450 2E1 activity triggered a strong genetic response to TCE. Particularly, cytochrome p450s, glutathione S-transferases, glucosyltransferases, and ABC transporters in the CYP2E1 transgenic hybrid poplar plants were highly expressed compared with in vector controls.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Jun Won</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>School of Forest Resources, College of the Environment, University of Washington, Seattle, WA 98195, USA. jwkang75@uw.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilkerson</LastName><ForeName>Hui-Wen</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Farin</LastName><ForeName>Federico M</ForeName><Initials>FM</Initials></Author><Author ValidYN="Y"><LastName>Bammler</LastName><ForeName>Theo K</ForeName><Initials>TK</Initials></Author><Author ValidYN="Y"><LastName>Beyer</LastName><ForeName>Richard P</ForeName><Initials>RP</Initials></Author><Author ValidYN="Y"><LastName>Strand</LastName><ForeName>Stuart E</ForeName><Initials>SE</Initials></Author><Author ValidYN="Y"><LastName>Doty</LastName><ForeName>Sharon L</ForeName><Initials>SL</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P42 ES004696</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P42 ES004696-23</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>03</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Funct Integr 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Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014241" MajorTopicYN="N">Trichloroethylene</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>02</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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IdType="pubmed">11809449</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 1998 Aug;106 Suppl 4:1001-4</Citation><ArticleIdList><ArticleId IdType="pubmed">9703485</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1750-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9990096</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2001 Jun;126(2):564-74</Citation><ArticleIdList><ArticleId IdType="pubmed">11402187</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Pollut. 2000 Feb;107(2):209-15</Citation><ArticleIdList><ArticleId IdType="pubmed">15092997</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Phytoremediation. 2004;6(2):157-67</Citation><ArticleIdList><ArticleId IdType="pubmed">15328981</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16816-21</Citation><ArticleIdList><ArticleId IdType="pubmed">17940038</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2003 Jun 24;4:26</Citation><ArticleIdList><ArticleId IdType="pubmed">12823867</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechnol Bioeng. 2006 Oct 20;95(3):399-403</Citation><ArticleIdList><ArticleId IdType="pubmed">16862598</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytochemistry. 2001 Dec;58(7):1055-65</Citation><ArticleIdList><ArticleId IdType="pubmed">11730869</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacogenetics. 1994 Oct;4(5):225-41</Citation><ArticleIdList><ArticleId IdType="pubmed">7894495</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2004;5(10):R80</Citation><ArticleIdList><ArticleId IdType="pubmed">15461798</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2000;1(6):REVIEWS3003</Citation><ArticleIdList><ArticleId IdType="pubmed">11178272</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2003 Nov;133(3):1397-406</Citation><ArticleIdList><ArticleId IdType="pubmed">14551330</ArticleId></ArticleIdList></Reference><Reference><Citation>Appl Environ Microbiol. 1988 Dec;54(12):3086-91</Citation><ArticleIdList><ArticleId IdType="pubmed">3223771</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2001;2(2):REVIEWS3004</Citation><ArticleIdList><ArticleId IdType="pubmed">11182895</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2002 Nov;130(3):1497-505</Citation><ArticleIdList><ArticleId IdType="pubmed">12428014</ArticleId></ArticleIdList></Reference><Reference><Citation>Ecotoxicol Environ Saf. 1997 Mar;36(2):118-22</Citation><ArticleIdList><ArticleId IdType="pubmed">9126428</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Plant Biol. 2000 Apr;3(2):153-62</Citation><ArticleIdList><ArticleId IdType="pubmed">10712958</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Appl Genet Mol Biol. 2004;3:Article3</Citation><ArticleIdList><ArticleId IdType="pubmed">16646809</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Res Toxicol. 2001 Apr;14(4):451-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11304134</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 Jul 24;424(6947):464-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12861225</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Sep 15;313(5793):1596-604</Citation><ArticleIdList><ArticleId IdType="pubmed">16973872</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem. 2002 Jun;10(6):1731-41</Citation><ArticleIdList><ArticleId IdType="pubmed">11937332</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2001 Jan 1;29(1):102-5</Citation><ArticleIdList><ArticleId IdType="pubmed">11125061</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Biotechnol. 2008 May;26(5):225-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18353473</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO Rep. 2005 Jun;6(6):497-501</Citation><ArticleIdList><ArticleId IdType="pubmed">15940279</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Plant Biol. 1998 Jun;1(3):258-66</Citation><ArticleIdList><ArticleId IdType="pubmed">10066594</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Mol Life Sci. 2001 May;58(5-6):737-47</Citation><ArticleIdList><ArticleId IdType="pubmed">11437235</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Soc Trans. 2005 Aug;33(Pt 4):796-801</Citation><ArticleIdList><ArticleId IdType="pubmed">16042601</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2008 Dec;56(6):963-74</Citation><ArticleIdList><ArticleId IdType="pubmed">18702669</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell Rep. 2003 Jun;21(9):829-37</Citation><ArticleIdList><ArticleId IdType="pubmed">12789499</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Bammler, Theo K" sort="Bammler, Theo K" uniqKey="Bammler T" first="Theo K" last="Bammler">Theo K. Bammler</name><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P" last="Beyer">Richard P. Beyer</name><name sortKey="Doty, Sharon L" sort="Doty, Sharon L" uniqKey="Doty S" first="Sharon L" last="Doty">Sharon L. Doty</name><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M" last="Farin">Federico M. Farin</name><name sortKey="Strand, Stuart E" sort="Strand, Stuart E" uniqKey="Strand S" first="Stuart E" last="Strand">Stuart E. Strand</name><name sortKey="Wilkerson, Hui Wen" sort="Wilkerson, Hui Wen" uniqKey="Wilkerson H" first="Hui-Wen" last="Wilkerson">Hui-Wen Wilkerson</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Kang, Jun Won" sort="Kang, Jun Won" uniqKey="Kang J" first="Jun Won" last="Kang">Jun Won Kang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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